Haopeng Sun Selected Research

Butyrylcholinesterase

9/2022	A highly effective and stable butyrylcholinesterase inhibitor with multi-faceted neuroprotection and cognition improvement.
1/2022	Design, synthesis, biological evaluation and molecular modeling of N-isobutyl-N-((2-(p-tolyloxymethyl)thiazol-4yl)methyl)benzo[d][1,3] dioxole-5-carboxamides as selective butyrylcholinesterase inhibitors.
1/2021	Structure and therapeutic uses of butyrylcholinesterase: Application in detoxification, Alzheimer's disease, and fat metabolism.
1/2021	Synthesis and bio-evaluation of a novel selective butyrylcholinesterase inhibitor discovered through structure-based virtual screening.
1/2021	Highly Potent and Selective Butyrylcholinesterase Inhibitors for Cognitive Improvement and Neuroprotection.
1/2020	Design, Synthesis, and Evaluation of Acetylcholinesterase and Butyrylcholinesterase Dual-Target Inhibitors against Alzheimer's Diseases.
1/2019	Expansion of the scaffold diversity for the development of highly selective butyrylcholinesterase (BChE) inhibitors: Discovery of new hits through the pharmacophore model generation, virtual screening and molecular dynamics simulation.
1/2018	Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer's disease.
5/2017	Recent progress in the identification of selective butyrylcholinesterase inhibitors for Alzheimer's disease.

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Haopeng Sun Research Topics

Disease

28	Alzheimer Disease (Alzheimer's Disease) 09/2022 - 01/2016
25	Neoplasms (Cancer) 01/2022 - 05/2012
9	Neurodegenerative Diseases (Neurodegenerative Disease) 09/2022 - 05/2017
4	Hypoxia (Hypoxemia) 01/2022 - 12/2015
3	Inflammation (Inflammations) 10/2021 - 11/2014
2	Hepatocellular Carcinoma (Hepatoma) 01/2022 - 01/2020
2	Metabolic Diseases (Metabolic Disease) 10/2021 - 10/2020
2	Carcinogenesis 02/2021 - 01/2020
2	Prostatic Neoplasms (Prostate Cancer) 02/2020 - 01/2020
2	Cardiac Arrhythmias (Arrythmia) 06/2014 - 01/2014
1	Parkinsonian Disorders (Parkinsonism) 01/2022
1	Parkinson Disease (Parkinson's Disease) 01/2022
1	Cognitive Dysfunction 11/2021
1	Cardiovascular Diseases (Cardiovascular Disease) 10/2021
1	Bites and Stings (Sting) 02/2021
1	Infections 02/2021
1	Substance-Related Disorders (Drug Abuse) 01/2021
1	Bipolar Disorder (Manic Depressive Psychosis) 01/2021
1	Dementia (Dementias) 01/2021
1	Cocaine-Related Disorders (Cocaine Addiction) 01/2021
1	Carcinoma (Carcinomatosis) 10/2020
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 04/2020
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2020
1	Atherosclerosis 01/2020
1	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2020
1	Osteitis Deformans (Paget's Disease of Bone) 01/2020
1	Sarcoma (Soft Tissue Sarcoma) 01/2020
1	Colorectal Neoplasms (Colorectal Cancer) 02/2019
1	Ovarian Epithelial Carcinoma 11/2018
1	Ovarian Neoplasms (Ovarian Cancer) 11/2018
1	Melanoma (Melanoma, Malignant) 01/2018

Drug/Important Bio-Agent (IBA)

9	ButyrylcholinesteraseIBA 09/2022 - 05/2017
5	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2015
5	Cholinesterase Inhibitors (Anticholinesterases)IBA 01/2021 - 10/2018
5	Biological ProductsIBA 12/2020 - 12/2018
5	LigandsIBA 01/2020 - 01/2017
4	Tacrine (Cognex)FDA Link 01/2020 - 01/2017
3	Pharmaceutical PreparationsIBA 12/2021 - 01/2018
3	Acetylcholine (Acetylcholine Chloride)FDA Link 11/2021 - 01/2021
3	AcetylcholinesteraseIBA 11/2021 - 01/2016
3	Phosphotransferases (Kinase)IBA 01/2021 - 04/2020
3	Cholinergic Agents (Cholinergics)IBA 01/2021 - 05/2017
3	Cholinesterases (Cholinesterase)IBA 12/2020 - 12/2018
3	EnzymesIBA 12/2018 - 09/2013
2	Hormones (Hormone)IBA 01/2022 - 10/2020
2	Monophenol Monooxygenase (Tyrosinase)IBA 01/2022 - 01/2018
2	CytokinesIBA 01/2022 - 02/2021
2	Glycogen Synthase KinasesIBA 11/2021 - 01/2021
2	Miconazole (Monistat)FDA LinkGeneric 01/2021 - 01/2018
2	Glycogen Synthase Kinase 3IBA 01/2021 - 12/2020
2	Carbolines (Beta-Carbolines)IBA 01/2020 - 01/2018
2	cinnamic acidIBA 01/2020 - 12/2018
2	beta-lapachoneIBA 03/2016 - 07/2014
1	Phosphodiesterase InhibitorsIBA 03/2022
1	Biomarkers (Surrogate Marker)IBA 01/2022
1	resorcinol (resorcin)IBA 01/2022
1	2-chloro-5-nitrobenzanilideIBA 01/2022
1	tetramethylpyrazineIBA 01/2022
1	Aldo-Keto Reductase Family 1 Member C3IBA 01/2022
1	neuromelaninIBA 01/2022
1	Histone Deacetylase 6IBA 12/2021
1	Glycogen Synthase Kinase 3 betaIBA 12/2021
1	Neuroprotective AgentsIBA 11/2021
1	Interferon Type IIBA 02/2021
1	InterferonsIBA 02/2021
1	Hypnotics and Sedatives (Sedatives)IBA 01/2021
1	Proteolysis Targeting ChimeraIBA 01/2021
1	Antihypertensive Agents (Antihypertensives)IBA 01/2021
1	AlkaloidsIBA 01/2021
1	Therapeutic UsesIBA 01/2021
1	Scopolamine (Hyoscine)FDA Link 01/2021
1	sertaconazole FDA Link 01/2021
1	Cocaine (Cocaine HCl)IBA 01/2021
1	Drug CarriersIBA 04/2020
1	Anaplastic Lymphoma KinaseIBA 04/2020
1	Oncogene Proteins (Oncogene Protein)IBA 03/2020
1	snake venom protein C activatorIBA 02/2020
1	Cysteine (L-Cysteine)FDA Link 01/2020
1	Glutamine (L-Glutamine)FDA Link 01/2020
1	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 01/2020
1	Alanine (L-Alanine)FDA Link 01/2020
1	Serine (L-Serine)FDA Link 01/2020
1	SolutionsIBA 01/2020
1	ThiadiazolesIBA 01/2020
1	Neurotransmitter Agents (Neurotransmitter)IBA 01/2020
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 01/2020
1	2-(N-cyclohexylamino)ethanesulfonic acid (CHES)IBA 11/2019
1	Phosphatidylinositols (Phosphatidylinositol)IBA 10/2019
1	CateninsIBA 02/2019
1	Programmed Cell Death 1 ReceptorIBA 01/2019
1	B7-H1 AntigenIBA 01/2019
1	ferulic acid (sodium ferulate)IBA 12/2018
1	src-Family KinasesIBA 11/2018
1	Paclitaxel (Taxol)FDA LinkGeneric 11/2018
1	Donepezil (Aricept)FDA LinkGeneric 10/2018

Therapy/Procedure

7	Therapeutics 01/2020 - 01/2015
1	Immunotherapy 02/2021
1	Oral Administration 01/2021
1	Nursing Care 01/2021
1	Activator Appliances (Function Activator) 01/2020